From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. My other vet never brought this up when discussing my MAS. Because of their similarity to Heartgard, Ive placed them in the same caution category. Thank you for bringing this to my attention! Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. I found it extremely helpful & educational. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. This organic powder is great for a variety of uses. Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Dash is MDR1 mutant/normal. In summary, use with caution. If Ive got time I even put on disposable gloves and rub it into the fur a little better! These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Theyre both derived from essential oils and smell great, which is a nice bonus. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Thanks much for the info before I bought anything! The vet is really no help. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Is this vaccine something youve heard of? One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. I have a cat myself, so I appreciate the information. Simparica Trio is proven to kill 5 species of ticks. I went through Paw Print Genetics to save money. My dog has been tested and is mutant/normal (MDR1). This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . The flavored, chewable tablets were consumed . After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. Is Simparica Trio safe for dogs with MDR1? They both have tolerated Bravecto very well.no noticeable side effects. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. They were extremely helpful people. The vet thought he would be nice and put Advantage Multi on our cats. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . Should I give them Trifexis or Sentinel Spectrum? Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. If your Collie doesnt play like that, you should be fine. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. We recently switched our dogs to a new product called Simparica Trio. For my Aussie mix, Ive had success using Advantix II. I have a one year old Aussie mix. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! Hi Vicki, In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. I just had my vet mention the mdr1 gene today in passing. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. My Aussie/Pyrenees mix has had no issues with it, for instance. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. Their treatment for this was nexgard and medicated baths. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). If your dogs arent reacting to it, why are you switching? Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. Waxman and Brooks both recommend it. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. I would say you are right to be concerned, and Ill give some info why. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. That indicates it is a strong chemical compound, so do watch for skin irritation. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. Your article was appreciated and helpful! I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) (This is for all dogs, not just for dog breeds at-risk for MDR1.) Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Thank you for all the research, it was all so helpful. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. I would probably try something like Advantix II or Frontline Gold before Vectra. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Seven Collies sound like a lot of work but also very wonderful! Simparica trio prescribed to 10 wk aussie pup. Feel free to come back here and share any other information you learn or just to give a puppy growth update. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. Second, Id like to ask a question if you dont mind. She is just 1 year old. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Frontline Gold and Frontline Shield. My dogs are on Sentinel right now and Frontline Gold. The main goal of this medication, according to the FDA, is; Simparica Trio treats and protects against harmful parasites. Its worth making a phone call to see what they would recommend for your pup. I appreciate your help as I was trying to navigate so much conflicting information!! Last year I used Frontline Plus with no issues. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Is hartz ultraguard ear mite treatment for dogs safe? Im hoping to get a Smoothie myself in the future. (Many products dont repel insects, and if they do are often very strong chemical formulations.). That averages out to about 212 deaths per year. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. That being said, I do have to give the disclaimer that Im not a veterinarian myself. 1x 10mg tablet for 5.6 to 11 pounds. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Congratulations on the new kitten. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. $153.89. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Thank you! The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. (Of course, skin irritation can happen with any topical product.) Thank you for the research and the detailed info on each product. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Super useful research. . So called vet and they said topically we should try Parastar Plus. However, it did make my Collies too itchy. Now: $92.79. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. What an awesome article. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. Hi Emily, do you know if panacure is a safe wormer? Im leaning toward Frontline Plus based on what you wrote. Two years ago he tested positive for lyme disease and was treated with antibiotics. I appreciate the research in this thank you! Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. It was both well written, and concise. I hate to use anything, but also tired of keeping my dogs in a bubble. Eliminate fleas before they lay eggs. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Fleas start to bite within 5 minutes. Simparica Trio is an all-in-one monthly chewable treatment for dogs. My pleasure! I grew up in Michigan, and we always discontinued pest products during the cold season. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Your sense of humor is enlightening also. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Also what can be used for giardia? I like Frank so much that I had to give him his own story. . Id like to have a Smooth Collie in the future. We are waiting for the results from her test for the MDR1 gene. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. We have an 11 year old tricolor rough coat collie. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Thank you very much! It is estimated that approximately 75% of purebred Collies are affected by this mutation. Simparica is administered once a month as a flavored chewable. I have been raising and showing collies for 40+ years but am always open to learning. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. This is so thorough and helpful! Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. Thank you for the warning. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Thank you for fostering! But of course, do talk to your vet and see what they know. I was unaware of MDR1 Mutation drug reactions at the time. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Simparica Trio is well tolerated in dogs with a deficient multidrugresistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose 1 THE SIMPARICA TRIO RANGE INCREASING COMPLIANCE FROM 2 MONTHS PER YEAR TO 12 WITH VETPOST COULD INCREASE REVENUE BY 600% Grupo de perros 1x, 3x y 5x veces la dosis. Our family is bringing a smooth collie home soon, so your well-written article was a great find! The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. From what youve told me, that does sound highly suspect. ? Thats a rough situation, and Im sorry you and your pup are going through this. We do, however, have lots of deer ticks (also known as black legged ticks). I can live with that. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. Best of luck with your new girl! Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Hi, Thank you for this helpful article. Additionally, it can be used to treat and control sarcoptic mange. I think this is a couple years old. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Mar 2013. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. For the majority of dogs, Advecta is probably fine! Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . 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