This is so awful. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Especially after seeing these post. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. Weighing your dog regularly will ensure that you are using the correct product size. Im convinced it was caused by this drug. He is just laying in his crate . This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. It hurts to see this and infuriating to know these stories are out here and we did not do the research before giving our little guys this poison. We will have blood work and results this evening. He walked outside peed then tried to come back in the house but his legs gave out . Call the FDA. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. Head down, tail down, will stand in a corner and stare at the wall. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. She continued to have seizures even she was on phenobarbital. I do believe it caused her blindness. My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! Them I took him to a vet for check up and to my horror, he has fleas and a tick. I thought maybe my dog had a bladder infection or got into something that upset her gut. All content contained in this article is sourced from public sources or the manufacturer. Can my dog still get Lyme disease from a tick that was in him. She is absolutely miserable and we're hoping she makes it. The flea components vary but having had one seizure you're now prone to being sensitive to even the "safer" ones. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. I have been giving my lab puppy (6 months old now) Simparica Trio since October. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. supply) at Chewy.com. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? We did skin scrape and they kept saying allergies. I was furious with the drug and the prescriber too. He first started with seizures and losing weight in June after giving him Simparica. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. Does anyone know of anything we can give her to help get this out of her system? The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. Side effects with Simparica are not common. It really helped us to put this diarrhea condition in perspective. But im 99% sure the simparica is what caused it. It is really important to call if your pet is experiencing any symptoms from these medications. Naturally, I want to make sure that she never has to go through that again. Vet gave her a shot which stopped it. Hi, any chance you did a spinal tap? We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. She does have history of seizures. My dog is still having tremors 5 months after taking Simparica. Good bless you all. The cardiologist found no heart condition that would cause this. The very next day he had diarrhea, and had it for 6 days. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! I'm so sorry. Random vomitting is no fun either. The only thing the vet can say, was a sore neck. Please do not use this drug. Simparica Trio is not effective against adult heartworms. We did not make the connection until today. Decreased conscious proprioception. I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. Our Pickles died last year after just 3 doses, and our vet basically said we were crazy. This is worth the cost to buy a six-pack of protection. Lethargic and confused. She also started drinking excessively, and peeing in the house. Doubtful our dog will be given Simparica again. Im still confused. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. He was very anxious when I left him and picked him up. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Omg this is horrible. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. Since the weather was turning cold, I stopped giving her the Simparica until spring. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. I wish I read these side effects before my vet recommended Simparica Trio for my 12 week old Bichon. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. He is very whinny and is drinking a lot of water. This was the only thing we changed, I am convinced this is what did it to her. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . I can tell something is off with her I just couldnt figure it out. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. for flea and ticks? I will post an update 7 days later. My dog is having seizures. Vet trip and meds $400! My shepherd got it the following month and I called the vet again and she prescribed probiaotics and anti diarrhea meds again. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. Today, he wouldn't eat or drink any water. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. We hope this will solve our problems and he can live a healthy and happy life. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. . Im switching back to the old stuff. She never did that before! Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. She went 11 days with no seizures and then had another gran mal. I dont know. Also - do NOT use Bravecto for females you intend to breed. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications." He has been very lethargic, he was an extremely playful pup. Didnt notice anything with first dose. Over time, I spent 7k to save here but to no avail. He is starting to get better. This medication must really be strong to do Flea tic and heart worm etc. He said it would take care of ticks and Trifexis doesn't. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. There is a petition in Australia to have this drug banned through change.org, which I've signed. This will kill fleas and ticks. Although these products can and have been. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. . I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). Yesterday one baby threw up four times within one hour of taking her chewable. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Will it get worse Will he get better? My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . And both of my other labs, basically house dogs, ended up with a droopy left eye. He already has canine dementia on and off. So sorry! I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. Im not sure if the simperica is the cause. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. Eyes roll back. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. I feel like it was a massive overdose. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. I thought it was them not liking the food and made a change. How is Simparica Trio Chewable Tablets for Dogs sold? Two weeks after I made the post above our girl started having seizures and we had to put her down. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. Did you go to the vets or not? Glad i held off on the free sample i was given! Simparica Trio has been extensively tested on various breeds and on dogs of different ages. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? I'm more concerned about fleas and heartworms and Trifexis is just fine for that. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. Has there been any improvement if so how long after did it take ? Im so angry at these drug companies and vets for selling this crap. She was being seen by her regular vet and was put on antibiotics. My Labradoodle had extreme diarrhea last night. I will never give my dog this medication again. Overly anxious. Some reports showed the dogs could have simparica seizures. He had his second dose on 3rd July. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. She seems to be feeling better but still very concerned of why these levels are still up. No problem eating. I gave the 1st one to my dog, 1st of this month. A vet for check up and to my horror, he was very anxious when i left him and him. 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